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A complete of 3 % of Lively material is excreted in urine as unchanged Energetic substance. Tapentadol is In addition metabolised to N-desmethyl tapentadol (thirteen %) by CYP2C9 and CYP2C19 and also to hydroxy tapentadol (two %) by CYP2D6, that happen to be even more metabolised by conjugation. Therefore, active substance metabolism mediated by cy